Japanese Rare Disease Models & Mechanisms Network

2nd International Symposium for Model
Organism Research on Human Rare Diseases

About J-RDMM

About IRUD-Beyond and Japanese Rare Disease Models & Mechanisms Network.

Model researcher

Registration and application form for the Japanese model organism researcher.

Rare disease researcher

Research application form of candidate variant for rare disease researcher.

Results of J-RDMM

About J-RDMM

Japan has a long history of tackling to so call “Nan-byo” (intractable diseases) mostly led by Ministry of Health, Labor and Welfare. IRUD (Japan’s Initiative on Rare and Undiagnosed Diseases) was started with the support of AMED and numerous disease (candidate) genes were identified with the aid of NGS. To utilize and extend the achievements of IRUD research, IRUD Beyond projects were launched at November of 2017 aiming to achieve below subjects.

  • Beyond diagnosis: Innovative medical drug candidates will be invented by targeting novel, single pathological mutations discovered in IRUD research.
  • Beyond genotyping: Innovative technologies will be applied to cases that remain unsolved after next generation sequencing (NGS)― based genome analysis.
  • Beyond borders: International data sharing will be facilitated even more in such a way that currently inaccessible but medically valuable databases get integrated into globally compatible systems.

Model organisms approach is effective to resolve these problems. Indeed, we have witnessed how the Canadian RDMM (Network) has so effectively addressed this problem by connecting the clinical and model organism researchers’ communities and providing catalyst grants to support collaborative functional characterization research. Accordingly, our model organism project as Japanese RDMM, is aiming to identify biological mechanisms of rare diseases under tight interaction between IRUD researchers and model organism researchers. We are strongly hoping that our new challenge will end up with fruitful success.

Project organization

J-RDMMN project is promoted under the Initiative on Rare and Undiagnosed Diseases (IRUD) by the Japan Agency for Medical Research and Development (AMED). The National Institute of Genetics serves as a representative organization, organize coordination committee and conducts nationwide recruitment of researchers on model organisms.


Project director

Prof. Ituro Inoue / National Institute of Genetics


IRUD researcher

  • Tadashi Kaname, National Center for Child Health and Development
  • Kenji Kurosawa, Kanagawa Children’s Medical Center
  • Kenjiro Kosaki, Keio University School of Medicine
  • Naomichi Matsumoto, Yokohama City University
  • Nobuhiko Okamoto, Osaka Women’s and Children’s Hospital

Model organism researcher

  • Toshiyuki Takano
  • Kiyoshi Naruse
  • Shohei Mitani

National Institute of Genetics

  • Masato Kanemaki
  • Koichi Kawakami
  • Kuniaki Saito
  • Hitoshi Sawa
  • Toshihiko Shiroishi
  • Hironori Niki
  • Shoko Kawamoto


  • Chihiro Hata

Application process

Model organism researchers, who hope to register in the Model Organism Researcher Registry and proceed to matching, are requested to complete the steps shown below.

Registration in the models researcher registry

  • Access the site to register model organism researcher information (https://j-rdmm.org/registry/) and input information including your name, affiliation, organisms and genes that you study, and academic papers that you have published.

Submission of the non-disclosure agreement

  • After completing the registration process, submit the Non-Disclosure Agreement (PDF format) via the Agreement Upload menu on the left.

Submission of the application form

  • Once your consent has been approved, you will be able to view the list of gene variants from the side menu. Please select a gene from this list and submit the application form (PDF format) via the ApplicationForm Upload menu on the left.

  • While we accept applications at any time so that we can begin analyzing requested variants as quickly as possible, the screening for the fiscal year in question may have ended due to budget constraints. Please contact us for the current status of your application as there may be additional budgetary provisions.

  • Format for the application form: Word file or PDF

Matching and reviewing

  • Following the preliminary reviewing of the documents, the research team (IRUD researchers + model organism researchers) will be determined by the Coordinating Committee, and the Secretariat will inform the applicants of the screening results. Selected research teams are requested to undertake necessary procedures at their respective organizations, with sufficient consultation on the contents of the joint research.

The distribution of research funds

  • When the joint research formally begins, the recommissioned research funds will be allotted to the affiliated institution by the National Institute of Genetics. Please contact us for inquiries as the amount of the recommissioned research funds may vary depending on the budget.

For information and inquiries

National Institute of Genetics. IRUD-Beyond J-RDMM office

E-mail address: irud-beyond (at) nig.ac.jp

About variant research application

IRUD researcher who want coordinate resrearch with model organisms researcher、please send the application form by e-mail to the address below.

For information and inquiries

National Institute of Genetics. IRUD-Beyond J-RDMM office

E-mail address: irud-beyond (at) nig.ac.jp


Project Director

Prof. Ituro Inoue / National Institute of Genetics

irud-beyond (at) nig.ac.jp